François Bertaux

quantitative biology


I am an engineer and mathematician turned quantitative biologist.

In 2018, I joined Institut Pasteur in Paris as a tenured research engineer. I am part of the InBio team, led by Gregory Batt. We try to invent new ways of investigating cellular processes, using optogenetic control, optimal experimental design, and lab automation.

Previously, I did a postdoc at Imperial College London with Sam Marguerat and Vahid Shahrezaei. I worked with fission yeast (S. pombe), a nice model organism that we use to address fundamental questions about the interplay between growth, cell size and gene expression. I was combining experiments (continuous culture, genetic engineering, single-cell microscopy) with mathematical and computational modeling.

Before that, my PhD work was purely computational, yet highly data-driven. I was then at Inria, Paris working with Dirk Drasdo and Gregory Batt. One main topic of my PhD work was to investigate in-silico the molecular mechanisms behind the resistance of cancer cells to the death ligand TRAIL. To do that, I developped a cell-based (each cell is represented individually) multi-scale (cellular decisions are controlled by biochemical reaction pathways simulated in each cell) approach to model the dynamics of cell populations.

I am very enthusiastic about the automation of biological experiments (at all scales of cost and throughput). Together with a formal, model-based representation of cells and experiments, I think we have a winning combination for accelerating quantitative biology.

cells, real and virtual

Contact: Email. Also on ResearchGate, LinkedIn, twitter.